Polymorphism of Clara Cell 10-kD Protein Gene of Sarcoidosis
نویسندگان
چکیده
منابع مشابه
Polymorphism of Clara cell 10-kD protein gene of sarcoidosis.
Clara cell 10-kD protein (CC10) exhibits potent antiinflammatory properties. G38A polymorphism was found in the CC10 gene. We investigated the genetic influence of the allele on the development of sarcoidosis using case control analysis in a Japanese population (265 sarcoidosis cases and 258 control subjects). The A allele frequency in sarcoidosis cases (45.1%) was significantly higher than hea...
متن کاملTissue-specific expression of the gene coding for human Clara cell 10-kD protein, a phospholipase A2-inhibitory protein.
Clara cell 10-kD protein (cc10kD), a secretory phospholipase A2 inhibitor, is suggested to be the human counterpart of rabbit uteroglobin (UG). Because cc10kD is expressed constitutively at a very high level in the human respiratory epithelium, the 5' region of its gene may be useful in achieving organ-specific expression of recombinant DNA in gene therapy of diseases such as cystic fibrosis. H...
متن کاملEnhancement of clara cell 10-kD protein (CC10) production from nasal epithelial cells by fexofenadine hydrochloride.
BACKGROUND Clara cell 10-kD protein (CC10) is well known to be an immuno-suppressive protein secreted from airway epithelial cells after inflammatory stimulation and is involved in the development of allergic disorders. Although histamine H1 receptor antagonists are used for the treatment of allergic disorders, the influence of the agents on CC10 production is not well understood. In the presen...
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Sarcoidosis is a systemic granulomatous disorder with a high rate of spontaneous regression. Clara cell 10-kDa protein (CC10), the predominant product of nonciliated bronchiolar epithelial cells, is a potent immunoregulatory and anti-inflammatory agent. CC10 levels were measured in sera and bronchoalveolar lavage (BAL) fluids from 31 sarcoidosis patients (nine progressive disease and 22 regress...
متن کاملfrequency of genetic polymorphism of the gene encoding 16kda clara cell secretory protein (cc16) in shiraz, iran
the clara cell protein (cc16) is a small and readily diffusible protein of 16 kda secreted by bronchiolar clara cells in the distal airspaces. mutation detection methods identified an adenine to guanine substitution in the cc16 gene at position 38 (a38g) downstream from the transcription initiation site within the non-coding region of exon 1. in the present study, the genetic polymorphism of cc...
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ژورنال
عنوان ژورنال: American Journal of Respiratory and Critical Care Medicine
سال: 2004
ISSN: 1073-449X,1535-4970
DOI: 10.1164/rccm.200304-559oc